- General: Weight loss, heat intolerance, insomnia, fatigue, increased sweating, restlessness, glucose intolerance
- Skin, Hair, Nails: Warm, most skin, alopecia, pruritus or itching, vitiligo, hyperpigmentation, pretibial myxedema (shin swelling), onycholysis
- Bone: Elevated calcium, elevated alkaline phosphatase, osteoporosis, acropachy (clubbing of fingers, distortion of the soft tissue of the fingers including pigmentation and overgrowth of the nails)
- Neuromuscular: Muscle weakness, tremors, muscle pain, nerve pain
- Mental hyperactivity, emotional lability, nervousness, anxiety, distractibility
- Gastrointestinal: Frequent bowel movements, diarrhea, increased appetite, elevated liver enzymes
- Respiratory: Shortness of breath
- Cardiovascular: Tachycardia (fast heartbeat), palpitations, increased cardiac output, abnormal enlargement of the heart, atrial fibrillation (irregular heart rhythm), angina (chest pains)
- Kidney: Frequent urination
- Ocular: Eyelid retraction, lid lag, exophthalmos (orbitopathy), conjunctivitis, diplopia (blurry vision), visual loss
- Reproductive: Irregular menses, gynecomastia, impotence, decreased fertility